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CAS No.: 512-04-9

薯蓣皂素 Catalog No. CSN12576

Synonyms: 薯蓣皂素;薯蓣皂苷元

Diosgenin, a natural product isolated and purified from the rhizomes of Dioscorea zingiberensis C.H.Wright, is an important natural source of steroidal hormones, and has favorable effects in the improvement of diabetes and regulation of lipid metabolism.

规格	价格	促销价格	库存	数量

400-920-2911

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生物活性

实验方案

技术信息

生物活性

描述Diosgenin, a natural steroidal saponin, has been found in many plants and owns a variety of biological activities. It can contribute to the cell death in HepG2 cells by damaging the stability of some special genes and affecting the normal cell cycle. Diosgenin effectively inhibits the migration in human breast cancer MDA-MB-231 cells. In vivo studies, diosgenin could prevent the loss of bone induced by retinoic acid in rats through regulating the level of some special proteins. Diosgenin has the ability of suppressing the cell growth, migration and invasion, as well as inducing apoptosis in liver cancer cells.
动物研究
剂量
Rat: 50 mg/kg, 100 mg/kg^[5] (i.g.); 20 mg/kg - 200 mg/kg^[6] (p.o.) Mice: 1 mg/kg - 125 mg/kg^[7] (p.o.)

给药途径
i.g., p.o.
参考文献

动物研究
剂量	Rat: 50 mg/kg, 100 mg/kg^[5] (i.g.); 20 mg/kg - 200 mg/kg^[6] (p.o.) Mice: 1 mg/kg - 125 mg/kg^[7] (p.o.)
给药途径	i.g., p.o.

[1] Cruz MS, Navoni JA, et al. Diosgenin induces genotoxic and mutagenic effects on HepG2 cells. Food Chem Toxicol. 2018.
[2] He Z, Chen H, et al. Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity. Phytomedicine. 2014;21(6):871-6.
[3] Zhao S, Niu F, et al. Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats. Ir J Med Sci. 2016;185(3):581-7.
[4] Chen Z, Xu J, et al. Diosgenin inhibited the expression of TAZ in hepatocellular carcinoma. Biochem Biophys Res Commun. 2018;503(3):1181-1185.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.4118 mL
- 12.0592 mL
- 24.1185 mL
- 5 mM
- 0.4824 mL
- 2.4118 mL
- 4.8237 mL
- 10 mM
- 0.2412 mL
- 1.2059 mL
- 2.4118 mL

技术信息

CAS号

512-04-9

储存条件

粉末: Keep in dark place,Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H42O3

运输

蓝冰

分子量

414.62

别名

薯蓣皂素;薯蓣皂苷元

溶解度

DMSO	Insoluble
Water	Insoluble
Ethanol	5.0 mg/mL (12.1 mM) warming

动物实验配方

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